Table 2.

Effects of l-arginine, 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene (NOC-18), hemin, carbon monoxide releasing molecule-3 (CORM-3), or inactive carbon monoxide releasing molecule-3 (iCROM-3) on the release of pro-inflammatory cytokines and chemokines in the pleural exudates 6 h after carrageenan (Cg) challenge.

Group	TNF-αa (pg/ml)	IL1-βb (pg/ml)	MCP-1c (pg/ml)
Saline	36.0 ± 0.6	167.3 ± 9.8	517.6 ± 27.6
Vehicled + Cg	1412.2 ± 109.4 ***	1897.4 ± 165.7 ***	2889.6 ± 183.6 ***
l-arginine + Cg	778.2 ± 100.6 ***, ###	1231.5 ± 220.3 **, #	1756.4 ± 176.9 ***, ###
NOC-18 + Cg	792.2 ± 106.3 ***, ###	883.7 ± 152.6 ###	1806.5 ± 161.7 ***, ###
Hemin + Cg	721.2 ± 72.8 ***, ###	930.5 ± 171.1 *, ##	1758.9 ± 205.8 ***, ###
CORM-3 + Cg	598.9 ± 88.9 **, ###	723.6 ± 131.0 ###	993.4 ± 125.1 ***, ###
iCORM-3 + Cg	1475.2 ± 89.3 ***	1844.9 ± 174.8 ***	3167.3 ± 178.4 ***

Each value represents the mean ± SEM of 5–10 rats. *, P < 0.05; **, P < 0.01; ***, P < 0.001 vs. saline controls. ^#, P < 0.05; ^##, P < 0.01, ^###, P < 0.001 vs. vehicle + Cg.

^aTNF-α, tumor necrosis factor-α.

^bIL-1β, interleukin-1β.

^cMCP-1, monocyte chemoattractant protein-1.

^dVehicle, saline.