Table 1.
Demographic and clinical characteristics of the study participants (N = 36).
| All (N = 36) | Non-delirious (n = 30) | Delirious (n = 6) | Group difference (p) | |
|---|---|---|---|---|
| Age at surgery (years) | 74.4 ± 3.9 | 74.3 ± 3.7 | 74.7 ± 5.3 | 0.808 |
| Education (years) | 16.0 ± 3.3 | 15.7 ± 3.4 | 17.3 ± 2.1 | 0.281 |
| Female sex (n, %) | 30, 83% | 25, 83% | 5, 83% | 1 |
| Proportion of knee/hip surgery | 17 (47%)/19(53%) | 13 (43%)/17 (57%) | 4 (67%)/2 (33%)) | 0.296 |
| Duration of anesthesia (mins) | 146.6 ± 32.4 | 141.1 ± 26.2 | 174.5 ± 47.5 | 0.019 |
| Duration of surgery (mins) | 92.9 ± 29.0 | 89.0 ± 27.5 | 112.7 ± 30.4 | 0.067 |
| Estimated blood loss (cc) | 203.5 ± 115.3 | 200.8 ± 123.3 | 216.7 ± 68.3 | 0.764 |
| Total length of stay (days) | 3.4 ± 0.9 | 3.3 ± 0.9 | 4.2 ± 1.0 | 0.037 |
| GCP (PREOP/PO1MO) | 61.5 ± 8.9/59.8 ± 9.3 | 62.4 ± 8.2/61.2 ± 8.3 | 56.1 ± 11.9/52.7 ± 11.2 | 0.148/0.037 |
| GDS (n, % ≥ 6) | 3, 0.083% | 1, 0.03% | 2, 33% | -* |
| CAM-S Peak | 3.1 ± 2.3 | 2.3 ± 1.2 | 6.8 ± 3.1 | <0.001 |
| CAM-S Sum | 5.6 ± 6.2 | 3.9 ± 2.7 | 14.2 ± 11.2 | <0.001 |
| Mean GM SUV60-90 (PREOP/PO1MO) | 1.0 ± 0.3/0.8 ± 0.2 | 1.1 ± 0.3/0.8 ± 0.2 | 0.9 ± 0.3/0.7 ± 0.2 | 0.118/0.230 |
| Mean WM SUV60-90 (PREOP/PO1MO) | 0.9 ± 0.2/0.7 ± 0.2 | 0.9 ± 0.2/0.7 ± 0.2 | 0.8 ± 0.3/0.7 ± 0.1 | 0.149/0.309 |
| Mean CSF SUV60-90 (PREOP/PO1MO) | 0.7 ± 0.2/0.7 ± 0.2 | 0.8 ± 0.2/0.7 ± 0.2 | 0.6 ± 0.2/0.6 ± 0.1 | 0.051/0.176 |
Note: PREOP = pre-operative baseline, PO1MO = post-operative 1-month follow-up, GCP = general cognitive performance, GSD = geriatric depression scale, CAM-S = Confusion Assessment Method-Severity, GM = gray matter, WM = white matter, CSF = cerebrospinal fluid, SUV = standardized uptake values. *p-value was not computed due to a small sample size.