Table I.

Case reports of CM that developed after patients were previously diagnosed with WM

Study	Year	Age (yrs)/Sex	Duration of WM (yrs)	Clinical presentation	Sites affected	IgM level	Lymph nodes/HSM	History of neuropathy	Special stains			Treatment	Outcome of treatment
									PAS	Congo red	IgM
Mascaro et al4	1982	48/M	4	Asymptomatic, discrete, smooth, pink, translucent, pearly and shiny papules, each 1-5 mm in diameter. Some of them show central crust and erosion.	Buttocks, thighs and legs	3400 mg/dL	Bilateral cervical lymphadenopathy	NM	+	NM	+ by DIF	Chlorambucil and prednisone (before onset of skin lesions)	NM
Cobb et al5	1992	59/M	4	Widespread eruption of 2-4 mm succulent erythematous excoriated papules, with confluence to plaques	Trunk, arms and legs	1520 mg/dL	None	NM	NM	NM	+ by DIF	Erythromycin and dapsone	Ineffective
												2% lindane lotion	Ineffective
												Daily prednisone	The eruptions improved.
												PUVA	The eruptions completely cleared.
Gressier et al1	2010	71/M	NM	Asymptomatic hyperkeratotic flesh-colored papules, some with central crust	Both knees	18.50 mg/dL	None	Peripheralneuropathy of all 4 limbs	+	- (for amyloid-specific stains)	+ by DIF	Rituximab and chlorambucil	Clearance of cutaneous lesions
Marchand et al6	2011	67/M	NM	Multiple erythematous, nonpruriginous,1-2 mm papules	Anterior face of the knees and calves	NM	NM	NM	+	-	+ by DIF	Bortezomib and rituximab	The skin lesions remained unchanged.
Camp and Magro2	2012	80/M	NM	Painful erythematous papules and nodules with central ulceration	Bilateral lower extremities and back of right hand	3016 mg/dL	NM	NM	NM	NM	+ by DIF	Patient received 2 doses of rituximab prior to the onset of the skin eruption.	NM
D'Acunto et al7	2014	70/M	15	Nodules covered by a thick hyperkeratotic layer. The lesions were extremely painful to pressure.	Soles of the feet	2290 mg/dL	NM	NM	+	-	+ by IHC	NM	NM
Oshio-Yoshii et al8	2017	63/M	1	Small reddish papules, some of which developed into discrete blister-like nodules	On and around the right medial malleolus	NM	NM	NM	+	-	+ by IHC	Intravenous immunoglobulin therapy	Ineffective
												Rituximab	Clearance of the skin lesions leaving pigmented macules, but lesions recurred after 6 months
Roupie et al9	2019	65/M	3	Papules covered by a thick hyperkeratotic layer	Soles of the feet	NM	NM	NM	+	-	+ by IHC	Rituximab, cyclophosphamide and corticosteroids	Complete regression of skin lesions and a partial hematologic response
Fayne et al3	2019	56/F	0.5	Numerous crusted papules and nodules with eschars	Disseminated across the body, including the face and fingers	280,200 g/dL	NM	NM	+	Weak +	+ by IHC	R-CHOP, rituximab, bendamustine and ibrutinib	Failed
Current case	2020	50/F	0.5	Multiple erythematous to hyperpigmented papules and nodules with central crust	Face, upper eyelids, and extensor aspects of both upper limbs	2200 mg/dL	Generalized lymphadenopathy and HSM	Peripheral Sensory neuropathy of both upper and lower limbs	+	-	+ by IHC	R-CHOP	Patient died after 2 sessions

DIF, Direct immunofluorescence; HSM, hepatosplenomegaly; IHC, immunohistochemistry; NM, not mentioned; PUVA, psoralen and ultraviolet A.