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. 2020 Jul 23;11:1603. doi: 10.3389/fimmu.2020.01603

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Copyright © 2020 Du, Yang, Ge, Liu, Zhang, Li, Li, Li, Liu, Dou, Yang and Duan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Different effects of M1 or M2 exosomes on the development of EAN. (A) Schematic illustration of experimental design for investigating the effects of M1 or M2 exosomes on development of EAN which was established by immunizing Lewis rats with BPM. (B,C) Clinical scores (B) and body weight (C) of EAN rats (n = 6 in each group) were evaluated and recorded every day. (D) Representative histology of sciatic nerves at day 13 post-immunization. H&E staining (upper), Luxol fast blue staining (lower). Data are expressed as mean ± SEM. *p < 0.05 vs. the control group, ^#p < 0.05, ^##p < 0.01 vs. the group of M2 exosomes, calculated by Kruskal-Wallis test followed by pairwise comparisons with not normally distributed data (day 10) or by one-way ANOVA followed by LSD test with normally distributed data at other time points.