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. 2020 Jul 23;10:1195. doi: 10.3389/fonc.2020.01195

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Copyright © 2020 Schrörs, Boegel, Albrecht, Bukur, Bukur, Holtsträter, Ritzel, Manninen, Tadmor, Vormehr, Sahin and Löwer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Numerical overview of selected neoantigen candidates for immunogenicity testing. 22 out of 49 assessed targets were immunogenic. (B) Immunogenicity testing of indels. Splenocytes of immunized mice (n = 3 per indel) were tested 5 days after the last immunization via IFN-γ ELISpot for recognition of overlapping 15-mer peptides covering the complete 4T1IND01 and 4T1IND02 sequence as indicated below the graphs (11 amino acid overlap, new amino acids are highlighted in red). Columns indicate mean of spot counts. Peptide IND2.8 elicited IFN-γ spots >2-fold over background (dotted line, medium control).