Figure 2.

The 3'RR and B-cell lymphomagenesis. (A) Schematic representation of several transgenic mouse models reporting c-myc 3'RR-driven deregulation leading to B-cell lymphomagenesis. B-cell lymphoma phenotypes are reported. Bibliographic references are reported (number in parenthesis). The “Mini-3'RR” contains the four transcriptional enhancers hs3a, hs1,2, hs3b, and hs4 but not the 3'RR palindromic sequences flanking hs1,2 and the DNA sequence between hs3a and hs4. (B) Long-range loop interactions between chromatin segments of the IgH locus comprise the mechanism of normal gene transcription regulation by the E_μ and 3'RR transcriptional enhancers. The example of the IgG₃ CSR process is schematized. Putative long-range interactions leading to c-myc oncogene deregulation in iMycE_μ mice are schematized.