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. 2020 Jul 23;10:1066. doi: 10.3389/fonc.2020.01066

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Copyright © 2020 Zhang, Bi, Liang, Wang, Zhang, Han, Li, Qiu, Fan, Chen, Jiao, Ye and Ding.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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VCAM1 promotes invasion and metastasis via activating EMT in CRC cells. (A) TCGA (n = 229) and GSEA (GSE41258, n = 195) analyses of the published CRC gene expression database were used to analyze the VCAM1-regulated gene signatures. (B) GEPIA was used to analyze the interaction between VCAM1 and key genes of the EMT program. (C) The expression of VCAM1, ZO1, Zeb, E-cad, N-cad, VIM, Snai1, and MMP9 in the indicated cells was detected by Western blotting.