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. 2020 Jul 23;10:1066. doi: 10.3389/fonc.2020.01066

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Copyright © 2020 Zhang, Bi, Liang, Wang, Zhang, Han, Li, Qiu, Fan, Chen, Jiao, Ye and Ding.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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VCAM1 plays a positive role in the progression of TEM in CRC cells. (A) TCGA (n = 229) enrichment analysis was adopted to analyze the VCAM1-related signatures. (B) Evaluation of CRC cell adhesive activity by tumor-endothelial cell adhesion assay in cells with VCAM1 upregulation (above) and downregulation (below). Red: tumor cells, green: HUVECs. Histogram analysis of the numbers of adherent cells (right). Scale bars: 50 μm. (C) Detection of TEM activity by transendothelial migration assay in the indicated cells (red). Scale bars: 50 μm. Histogram analysis of the numbers of transendothelial migrate cells (right). Error bars represent the mean ± SD from three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001.