Table 2.

LAMA2 mouse models.

Lama2 Mouse	Mutation	Laminin-α2 levels	CNS Involvement
			Myelination deficits	BBB Deficits	Other
dy/dy (Michelson et al., 1955)	Spontaneous mutation	Substantially reduced	Impaired oligodendrogenesis and myelination (Chun et al., 2003; Relucio et al., 2009).	Unknown	Elevated audiometric threshold response, degeneration of cochlear and vestibular structures (Pillers et al., 2002). Atrophy of motor neurons and abnormal neurotrophic factor expression in CNS (Sakuma et al., 2002)
dy2J/dy2J (Meier and Southard, 1970)	Spontaneous mutation; abnormal splicing and subsequent instability leads to a truncated protein that lacks the N-terminus	Expressed but lacking LN domain; modest reduction in levels	Unknown	Unknown	Long term plasticity was disrupted (Anderson et al., 2005).
dyW/dyW (Kuang et al., 1998)	Targeted knock-out; truncated protein	Very low to absent	Unknown	Unknown
dy3k/dy3k (Miyagoe et al., 1997)	Targeted knock-out	Absent	Impaired oligodendrogenesis and myelination (Relucio et al., 2012).	BBB dysfunction and increased permeability (Menezes et al., 2014).	Impaired NSC proliferation and attachment within the ventricular zone (Loulier et al., 2009; Relucio et al., 2012).