Figure 8.

Electrophysiological evaluation of tmc2a and tmc2b single mutants. Stimulus-evoked microphonic potentials measured from the otic vesicles of tmc2a^cwr3 (A) and tmc2b^cwr1 (B) animals with controls. Graphs of mean microphonic potentials from otic vesicles of tmc2a^cwr3 (C) and tmc2b^cwr1 (D) animals with controls. Mean microphonic potential of tmc2a^cwr3 ± SEM = 23.6 ± 3.4 μV (n = 5), mean microphonic potential of wild-type and heterozygous siblings = 80.3 ± 6.9 μV (n = 25; Mann–Whitney test, ^****P < 0.0001); mean microphonic potential of tmc2b^cwr1 ± SEM = 105 ± 12.9 μV (n = 6), mean microphonic potential of wild-type and heterozygous siblings = 83.1 ± 7.8 μV (n = 14; P = 0.13).