Table 1.
Genotypes
| Gene | Allele | Exon | Type | Target (5′ → 3′) | Genotype | DNA change | aa preserved/ total aa | DNA change description |
|---|---|---|---|---|---|---|---|---|
| tmc1 | cwr4 | 7 | Small deletion | TGGGCTGGTCATGGTTCCAG | tmc1cwr4 | 8-bp deleted | 385/990 | −8 bp at c.1155–1162 (−CATGGTTC) |
| cwr5 | 5 | Small deletion | Left: TTGTGGAGAAATATGAAG; Right: CAAAGGCAGGAAACTTTA | tmc1cwr5 | 1-bp deleted | 308/990 | −1 bp at c.926 (−T) | |
| tmc2a | cwr3 | 9 | Small deletion | AGGTCCCAATGCCCACCATG | tmc2acwr3 | 1-bp deleted/1-bp deleted | 349/916 | −1 bp at c.1050 (−C); −1 bp at c.1052 (−T) |
| cwr6 | Indel | tmc2acwr6 | 2-bp inserted/3-bp deleted | 350/916 | −3/+2 bp at c.1053–1055 (−GGT/+TG) | |||
| tmc2b | cwr1 | 3 | Small deletion | Left: TAGCAACACTTAGGAACA; Right: GGAGACTCAAGTGCTTGA | tmc2bcwr1 | 7-bp deleted | 145/892 | −7 bp at c.438–444 (−GCGCATG) |
| cwr2 | 7 | Small deletion | GGCCGAATCCTGCTCCTCTC | tmc2bcwr2 | 5-bp deleted | 266/892 | −5 bp at c.799–703 (−GAGGA) | |
| cwr8 | 6 | Small deletion | GGACTAAACCTTGTTCTCTT | tmc2bcwr8 | 5-bp deleted | 236/892 | −5 bp at c.710–714 (−TCTTC) |