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. 2020 Jul 23;14:783. doi: 10.3389/fnins.2020.00783

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Copyright © 2020 Damiano, De Benedetto, Longo, Giannotti, Fico, Siculella and Giudetti.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multivariate analysis of data from C8 or C10 treated U87MG cells. (A) Principal Component Analysis (PCA) of U87MG treated with C8 or C10 (N = 3). (B) Partial Least Squares Discriminant Analysis (PLS-DA) plot. The shaded areas indicate the 95% confidence ellipse regions based on the data points for individual groups. (C) Loading plot showing the most discriminative metabolites. (D) Heat map visualization based on 34 metabolites. Red: C10-treated cells; green: C8-treated cells; blue: CTR cells, respectively. The color key indicates metabolite values: dark blue: lowest; dark red: highest.