TABLE 3.

Pathway Analysis of metabolites from C8-treated vs CTR cells.

Pathway name	Match status	p-value	Impact
Purine metabolism	1/65	0.0026759	0.0
Pyrimidine metabolism	1/39	0.0026759	0.0
Valine, leucine and isoleucine biosynthesis	1/8	0.0091165	0.0
Nitrogen metabolism	2/6	0.0166	0.0
Propanoate metabolism	3/23	0.017297	0.04061
Aminoacyl-tRNA biosynthesis	6/48	0.018156	0.0
Tyrosine metabolism	4/42	0.019357	0.16435
Fatty acid biosynthesis	4/47	0.021364	0.01473
D-Glutamine and D-glutamate metabolism	3/6	0.029373	0.5
Starch and sucrose metabolism	1/18	0.036503	0.4207
Galactose metabolism	1/27	0.036503	0.03499
Neomycin, kanamycin and gentamicin biosynthesis	1/2	0.036503	0.0
Glyoxylate and dicarboxylate metabolism	7/32	0.038069	0.13493
Glutathione metabolism	1/28	0.039744	0.01966
Porphyrin and chlorophyll metabolism	1/30	0.039744	0.0
Alanine, aspartate and glutamate metabolism	10/28	0.041703	0.67629
Arginine biosynthesis	5/14	0.044703	0.11675

Pathways involved in C-8 treated cells with the number of metabolites that match in the indicated pathway; p is the original p-value calculated from the Enrichment Analysis; impact is the pathway impact value calculated from pathway topology analysis.