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. 2020 Jul 23;8:748. doi: 10.3389/fbioe.2020.00748

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Copyright © 2020 Babajani, Soltani, Jamshidi, Farjoo and Niknejad.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Drugs in MSCs. (1) Drugs enter MSCs through a variety of pathways: (a) drug transporters such as hCNT1 and hENT1, (b) endocytosis, (c) simple diffusion based on the chemical nature of chemotherapeutic drugs. (2) Some types of drugs such as paclitaxel metabolized in mitochondria, but there is no evidence of impressive inactivation. (3) Based on the antineoplastic mechanism of drugs, they are distributed among their place of action such as microtubule networks and centrioles. (4) Chemotherapeutic drugs may interfere with the normal gene expression pattern of MSCs, which mainly influence differentiation capacity. (5) Mesenchymal stem cells produce vesicles that contain drugs close to the cellular membrane. Drugs can be found in Golgi apparatus and Golgi-derived vesicles. (6) Existence of vesicles between MSCs and cancer cells suggests that drugs can be delivered to cancer cells in a vesicular system.