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. 2020 Jul 23;11:1681. doi: 10.3389/fmicb.2020.01681

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Copyright © 2020 Vitale, Pessi, Urfer, Locher, Zerbe, Obrecht, Robinson and Eberl.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Resistance fitness determinants for polymyxin B2 (PMB). The MA-plot (M for log ratio and A for mean average) shows the average of the normalized unique insertion density (nUID) between the PMB-treated sample and the untreated sample (log2) on the x-axis and the fold change of the nUID between the two samples (log2) on the y-axis. The 58 genetic determinants likely involved in bacterial fitness upon PMB exposure are highlighted in red and genes of interest are named. NC, no change.