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. 2020 Jul 23;11:1681. doi: 10.3389/fmicb.2020.01681

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Copyright © 2020 Vitale, Pessi, Urfer, Locher, Zerbe, Obrecht, Robinson and Eberl.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Number and clustering of fitness determinants. (A) The identified resistance determinants for the investigated antibiotics substantially overlap. Thirteen genes impact susceptibility to all tested antibiotics and besides these genes, PMB and colistin (COL) share 21 fitness determinants and peptides (Pep.) 3 and 4 have 19 common genetic determinants. (B) Cluster dendrogram of the Tn-Seq generated in response to PMB, COL, L27-11, peptides 3 and 4 treatments using the Ward criterion and the Euclidean distance. Peptides PMB/COL and 4/3 were clustered in 100% of the 100,000 iterations (Bootstrap Probability; ***p-value < 0.01).