TABLE 3.
Validation of fitness genes in P. aeruginosa UCBPP-PA14.
| Locus tag | Description | Potential resistance | PMBa | COLa | L27-11a | 4a | 3a |
| PA14_08540 | mepM1 | PMB/COL/4 | 4 | 2 | 1 | 2 | 2 |
| PA14_12080 | sltB1 | All (ex. L27-11) | 4 | 2 | 1 | 1 | 1 |
| PA14_57100 | ampG | PMB/COL/4 | 4 | 4 | 1 | 1 | 1 |
| PA14_58090 | asmA | All | 8 | 16 | 1 | 1 | 2 |
| PA14_18370 | arnB | All | 64 | 32 | 8 | 8 | 2 |
| PA14_63160 | pmrB | All | 16 | 8 | 4 | 2 | 2 |
| PA14_49180 | phoP | All | 4 | 2 | 1 | 2 | 1 |
| PA14_49170 | phoQ | None | 1 | 1 | 1 | 1 | 1 |
| PA14_41260 | parR | All (ex. 3) | 4 | 16 | 1 | 1 | 1 |
| PA14_56940 | colS | None | 2 | 2 | 2 | 1 | 1 |
| PA14_63120 | speE | L27-11 | 2 | 1 | 4 | 1 | 1 |
aFold-change decrease in MICs (increased susceptibility) relative to the wild-type (1 = MIC between wild-type and mutant is unchanged). Data represent the values of three independent experiments performed in BM2 containing 20 μM Mg2+. ex., except antibiotics shown.