TABLE 4.
Minimum inhibitory concentrations of the peptides (PMB, L27-11, chimeras 3 and 4) in the presence (4 mM) or absence of spermidine in P. aeruginosa UCBPP-PA14 wild-type.
Test Agent | Without Spermidinea | With 4 mM Spermidinea |
L27-11 | 0.5 | 4 |
4 | 4 | 0.5 |
3 | 2 | 0.25 |
PMB | 50 | >100 |
aMICs of the different antibiotics were determined in BM2 containing 20 μM Mg2+ in microtiter plates. Data represent mode values of three independent experiments.