TABLE 1.

Bioprocess features selected by each surrogate modeling technique from Feature Set 1 (X = selected).

Feature	FS1-RF	FS1-GPR	FS1-MARS
Average DO concentration dd0	X
Average DO concentration gradient d0	X		X
Average DO concentration gradient dd2		X
Average DO concentration gradient dd6	X
Average DO concentration gradient dd7		X
d0 average pH gradient	X
dd0 average pH gradient		X
dd0 average acceleration of cell density normalized DO gradient	X
dd0–dd1 cell density gradient		X	X
dd1 aggregate size			X
dd1 cell density	X
dd2 average pH	X
dd7 average pH		X
dd3 aggregate size			X
dd3 average acceleration of DO gradient			X
dd3 average pH gradient	X
dd3 average acceleration of cell density normalized DO gradient			X
dd5 average pH gradient
dd5–dd7 aggregate size gradient	X
dd5–dd7 cell density gradient			X
dd7 cell density	X	X
Cell density normalized DO concentration dd2			X
Cell density normalized DO concentration dd3		X	X
Cell density normalized DO concentration dd7	X
Average cell density normalized DO concentration gradient dd2	X	X
Average cell density normalized DO concentration gradient dd5		X
Average cell density normalized DO concentration gradient dd7	X
IWP2 treatment time [h]			X
Preculture time [h]		X