Table 3.

All the studies included in this systematic review (the time-based cut-off points for defining early versus delayed cystectomy, the median follow-up, cancer stage/grade, and CIS percentage)

Source	Date	Patients, n	Early, n	Deferred, n	Time of RC post-diagnosis (early vs. delayed)	Median follow-up, months	Proportion of initial stage/grade	CIS, %
Ali-El-Dein et al., 2011 [14]	1990–2004	204	134	70	< 2 vs. > 2 years	77, 66 (early vs. deferred groups, respectively)	T1G1 (9.3%) T1G2 (77%) T1G3 (13.7%)	28.4
Kamat et al., 2006 [15]	1989–2004	30	12	18	deferred RC = after disease progression to cT2 or higher	32.1	Ta (11%) T1 (80%) micropapillary (100%)	13.4
Thalman et al., 2004 [16]	1980–1999	56	29	27	< 3 vs. > 3 months	82.8 (range: 2.4–198)	T1G3 (100%)	21.0
Gupta et al., 2007 [23]	1984–2003	167	89	34	< 3 vs. > 3 months	33.8 (0.4–177.1)	T1G3 (100%)	45.6
Dalbagni et al., 2009 [18]	1990–2007	333	274	59	< 3 vs. > 3 months	51.6	T1 (100%) high grade (97%)	23.0
Denzinger et al., 2007 [13]	1995–2005	105	54	51	median: 4 weeks vs. 11.2 months	120	pT1G3 (100%)	46.0
Dinney et al., 1998 [27]	1992–1994	34	20	14	median: 22 vs. 421 days	48 (range: 12–239)	T1G2/3 (100%)	−
Hautmann et al., 2009 [22]	1908–1986	274	124	99	< 90 vs. > 90 days	180	T1G3 (100%)	−
Jäger et al., 2011 [17]	1989–2006	278	141	77	< 1 vs. > 1 year	79 (0–242)	pTaG3 (7%), pT1G3 (72%)	21.0
Herr et al., 2001 [10]	1979–1984	35	26	9	< 2 vs. > 2 years	180	TaG3 (100%)	81.0