Table 2.

Cox proportional-hazards regression: uni- and multi-variate analysis of DFS

Variable (comparator)	DFS, Cox proportional hazard regression
	Univariate analysis		Multivariate analysis
	HR (95% CI)	p	HR (95% CI)	p
Age (> 60 vs. ≤ 60 years)	1.19 (0.77–1.84)	0.4268	−	−
Sex (male vs. female)	1.34 (0.83–2.16)	0.2266	−	−
ECOG-PS (≥ 2 vs. 0–1)	0.85 (0.31–2.34)	0.7620	−	−
Side (left)
Right	0.79 (0.50–1.26)	0.3301	0.97 (0.58–1.61)	0.9197
Bilateral	9.5 (2.78–32.7)	0.0003	6.59 (1.81–23.9)	0.0041
Histology (clear cell)
Papillary/chromophobe	0.58 (0.23–1.46)	0.2549	0.50 (0.19–1.29)	0.1530
Others	2.44 (1.24–4.81)	0.0094	1.59 (0.74–3.39)	0.2277
Fuhrman grade (3–4 vs. 1–2)	2.09 (1.34–3.26)	0.0011	2.21 (1.39–3.51)	0.0008
T (3b–4 vs. 1–3a)	1.65 (1.01–2.69)	0.0437	1.73 (1.04–2.87)	0.0324
N (1–2 vs. 0–x)	3.16 (1.68–5.92)	0.0003	2.23 (1.07–4.63)	0.0303