Table 1.

Main ¹⁸F-FDG PET hypometabolic findings for each patient in comparison to healthy subjects (p voxel < 0.001, p-cluster < 0.05, uncorrected)

	Cluster	Cluster	Voxel	voxel	Talairach coordinates			Localization
	k	p value	T score	p value	x	y	z
Case 1	286	0.023	5.97	< 0.001	4.0	30.0	− 27.0	Right rectal gyrus (BA11)
Case 2	3574	< 0.001*	6.92	< 0.001*	− 22.0	− 37.0	− 2.0	Left hippocampus
			6.64	< 0.001*	− 18.0	− 43.0	− 3.0	Left parahippocampal gyrus (BA19)
			5.39	< 0.001	− 18.0	− 16.0	− 13.0	Left parahippocampal gyrus (BA28)
			5.27	< 0.001	20.0	− 26.0	− 9.0	Right parahippocampal gyrus (BA28)
			4.70	< 0.001	− 8.0	− 50.0	4.0	Left cerebellar anterior lobe
			4.58	< 0.001	− 6.0	− 6.0	− 3.0	Hypothalamus
			4.48	< 0.001	− 6.0	− 16.0	− 1.0	Left thalamus
			4.35	< 0.001	18.0	3.0	− 17.0	Right parahippocampal gyrus (BA34)
			4.30	< 0.001	24.0	5.0	− 19.0	Right uncus (BA28)
			4.29	< 0.001	26.0	− 37.0	− 3.0	Right hippocampus
			4.18	< 0.001	6.0	20.0	− 25.0	Right rectal gyrus (BA11)
			4.13	< 0.001	2.0	− 32.0	− 22.0	Right cerebellar culmen
	604	0.001*	5.87	< 0.001	− 4.0	− 31.0	− 40.0	Medulla
			3.79	< 0.001	18.0	− 34.0	− 29.0	Pons
			3.71	0.001	12.0	− 35.0	− 40.0	Right cerebellar tonsil
	587	0.001*	5.29	< 0.001	− 4.0	− 12.0	37.0	Left cingulate gyrus (BA24)
			3.91	< 0.001	− 10.0	− 43.0	33.0	Left cingulate gyrus (BA31)
	390	0.007*	5.08	< 0.001	59.0	− 1.0	13.0	Right pre-central gyrus (BA6)
			4.91	< 0.001	61.0	− 23.0	14.0	Right post-central gyrus (BA40)
			4.48	< 0.001	63.0	− 36.0	15.0	Right superior temporal gyrus (BA22)

The k value represents the number of voxels inside a particular cluster. p values are all presented as uncorrected for multiple comparisons. p values still significant at p < 0.05 after correction for multiple comparisons using FWE method (family-wise error) are indicated with *. Talairach coordinates are expressed in mm. BA Brodmann Area