Table 2.
The information of related targets of the Tusizi-Sangjisheng herb pair.
| No. | Target name | Gene name | UniProt ID |
|---|---|---|---|
| 1 | 26S proteasome non-ATPase regulatory subunit 3 | PSMD10 | O75832 |
| 2 | 72 kDa type IV collagenase | MMP2 | P08253 |
| 3 | 78 kDa glucose-regulated protein | HSPA5 | P11021 |
| 4 | Acetylcholinesterase | ACHE | P22303 |
| 5 | Activator of 90 kDa heat shock protein ATPase homolog 1 | AHSA1 | O95433 |
| 6 | Androgen receptor | NCOA4 | Q13772 |
| 7 | Apoptosis regulator BAX | BAX | Q07812 |
| 8 | Arachidonate 5-lipoxygenase | ALOX5 | P09917 |
| 9 | ATP-binding cassette subfamily G member 2 | ABCG5 | Q9H222 |
| 10 | Baculoviral IAP repeat-containing protein 5 | BIRC5 | O15392 |
| 11 | Bcl-2-like protein 1 | BCL2L1 | Q07817 |
| 12 | Beta-2 adrenergic receptor | ADRB2 | P07550 |
| 13 | Caspase-8 | CASP8 | Q14790 |
| 14 | Cathepsin D | CTSD | P07339 |
| 15 | Caveolin-1 | CAV1 | Q03135 |
| 16 | CD40 ligand | CD40LG | P29965 |
| 17 | Cellular tumor antigen p53 | TP53 | P04637 |
| 18 | Claudin-4 | CLDN4 | O14493 |
| 19 | Coagulation factor VII | F7 | P08709 |
| 20 | C-reactive protein | CRP | P02741 |
| 21 | C-X-C motif chemokine 10 | CXCL10 | P02778 |
| 22 | C-X-C motif chemokine 11 | CXCL11 | O14625 |
| 23 | C-X-C motif chemokine 2 | CXCL2 | P19875 |
| 24 | Cyclin-dependent kinase inhibitor 1 | CDKN1B | P46527 |
| 25 | Cytochrome P450 1A1 | CYP1A1 | P04798 |
| 26 | Cytochrome P450 1B1 | CYP1B1 | Q16678 |
| 27 | Cytochrome P450 3A4 | CYP3A4 | P08684 |
| 28 | DDB1- and CUL4-associated factor 5 | DCAF5 | Q96JK2 |
| 29 | Dipeptidyl peptidase IV | DPP4 | P27487 |
| 30 | DNA topoisomerase 1 | TOP1 | P11387 |
| 31 | E-selectin | SELE | P16581 |
| 32 | Estrogen sulfotransferase | SULT1E1 | P49888 |
| 33 | ETS domain-containing protein Elk-1 | ELK1 | P19419 |
| 34 | G1/S-specific cyclin-D1 | CCND1 | P24385 |
| 35 | G2/mitotic-specific cyclin-B1 | CCNB1 | P14635 |
| 36 | Gamma-aminobutyric acid receptor subunit alpha-1 | GABRA1 | P14867 |
| 37 | Glutathione S-transferase Mu 1 | GSTM1 | P09488 |
| 38 | Heat shock factor protein 1 | HSF1 | Q00613 |
| 39 | Heme oxygenase 1 | HMOX1 | P09601 |
| 40 | Inhibitor of nuclear factor kappa-B kinase subunit alpha | CHUK | O15111 |
| 41 | Insulin receptor | INSR | P06213 |
| 42 | Interleukin-1 alpha | IL1A | P01583 |
| 43 | Interleukin-1 beta | IL1B | P01584 |
| 44 | Interleukin-10 | IL10 | P22301 |
| 45 | Interleukin-2 | IL2 | P60568 |
| 46 | Interleukin-6 | IL6 | P05231 |
| 47 | Interleukin-8 | CXCL8 | P10145 |
| 48 | Interstitial collagenase | MMP1 | P03956 |
| 49 | Mitogen-activated protein kinase 1 | Mapk1 | P63085 |
| 50 | mRNA of PKA catalytic subunit C-alpha | PRKACA | P17612 |
| 51 | Myc protooncogene protein | MYC | P01106 |
| 52 | Myeloperoxidase | MPO | P05164 |
| 53 | Neutrophil cytosol factor 1 | NCF1 | P14598 |
| 54 | Nuclear factor erythroid 2-related factor 2 | NFE2L2 | Q16236 |
| 55 | Nuclear receptor coactivator 2 | NCOA2 | Q15596 |
| 56 | Peroxisome proliferator-activated receptor alpha | PPARA | Q07869 |
| 57 | Peroxisome proliferator activated receptor delta | PPARD | Q03181 |
| 58 | Peroxisome proliferator activated receptor gamma | PPARG | P37231 |
| 59 | Plasminogen activator inhibitor 1 | SERPINE1 | P05121 |
| 60 | Poly [ADP-ribose] polymerase 1 | TNKS | O95271 |
| 61 | Potassium voltage-gated channel subfamily H member 2 | KCNH2 | Q12809 |
| 62 | Prostaglandin G/H synthase 1 | PTGS1 | P23219 |
| 63 | Protooncogene c-Fos | FOS | P01100 |
| 64 | Puromycin-sensitive aminopeptidase | NPEPPS | P55786 |
| 65 | RAC-alpha serine/threonine-protein kinase | AKT1 | P31749 |
| 66 | RAF protooncogene serine/threonine-protein kinase | RAF1 | P04049 |
| 67 | Ras association domain-containing protein 1 | RASSF1 | Q9NS23 |
| 68 | Ras GTPase-activating protein 1 | RASA1 | P20936 |
| 69 | Receptor tyrosine-protein kinase erbB-2 | ERBB2 | P04626 |
| 70 | Receptor tyrosine-protein kinase erbB-3 | ERBB3 | P21860 |
| 71 | Retinoic acid receptor RXR-alpha | RXRA | P19793 |
| 72 | Runt-related transcription factor 2 | RUNX2 | Q13950 |
| 73 | Serine/threonine-protein kinase Chk2 | CHEK2 | O96017 |
| 74 | Serum paraoxonase/arylesterase 1 | PON1 | P27169 |
| 75 | Sodium channel protein type 5 subunit alpha | SCN5A | Q14524 |
| 76 | Solute carrier family 2, facilitated glucose transporter member 4 | SLC2A4 | P14672 |
| 77 | Stromelysin-1 | MMP3 | P08254 |
| 78 | Thrombin | F2 | P00734 |
| 79 | Thrombomodulin | THBD | P07204 |
| 80 | Transcription factor AP-1 | JUN | P05412 |
| 81 | Transcription factor E2F1 | E2F1 | Q01094 |
| 82 | Transcription factor E2F2 | E2F2 | Q14209 |
| 83 | Transcription factor p65 | RELA | Q04206 |
| 84 | Trypsin-1 | PRSS1 | P07477 |
| 85 | Type I iodothyronine deiodinase | DIO1 | P49895 |
| 86 | Xanthine dehydrogenase/oxidase | XDH | P47989 |
| 87 | 2,4-Dienoyl-CoA reductase, mitochondrial | DECR1 | Q16698 |
| 88 | Acetyl-CoA carboxylase 1 | ACACA | Q13085 |
| 89 | ATP-citrate synthase | ACLY | P53396 |
| 90 | Coagulation factor Xa | F10 | P00742 |
| 91 | Cytochrome P450 2B6 | CYP2B6 | P20813 |
| 92 | Endothelin-converting enzyme 1 | ECE1 | P42892 |
| 93 | Glucose-6-phosphate 1-dehydrogenase | G6PD | P11413 |
| 94 | NADPH oxidase 1 | NOX1 | Q9Y5S8 |
| 95 | NADPH oxidase 3 | NOX3 | Q9HBY0 |
| 96 | Nitric oxide synthase, endothelial | NOS3 | P29474 |
| 97 | Peroxisomal acyl-coenzyme A oxidase 1 | ACOX1 | Q15067 |
| 98 | Peroxisomal bifunctional enzyme | EHHADH | Q08426 |
| 99 | Sterol regulatory element-binding protein 1 | SREBF1 | P36956 |
| 100 | Aldose reductase | AKR1B10 | O60218 |
| 101 | Amine oxidase [flavin-containing] B | MAOB | P27338 |
| 102 | Cyclin-A2 | CCNA2 | P20248 |
| 103 | Estrogen receptor beta | ESRRB | O95718 |
| 104 | Glutamate receptor 2 | GRIA2 | P42262 |
| 105 | Mitogen-activated protein kinase 14 | MAPK14 | Q16539 |
| 106 | Nitric oxide synthase, inducible | NOS2 | P35228 |
| 107 | Nuclear receptor coactivator 1 | NCOA1 | Q15788 |
| 108 | Protooncogene serine/threonine-protein kinase Pim-1 | PIM1 | P11309 |
| 109 | Serine/threonine-protein kinase Chk1 | CHEK1 | O14757 |
| 110 | 5-Hydroxytryptamine 2A receptor | HTR2A | P28223 |
| 111 | Alpha-1A adrenergic receptor | ADRA1A | P35348 |
| 112 | Alpha-1B adrenergic receptor | ADRA1B | P35368 |
| 113 | Caspase-9 | CASP9 | P55211 |
| 114 | Dopamine D1 receptor | DRD1 | Q95136 |
| 115 | Gamma-aminobutyric-acid receptor alpha-3 subunit | GABRA3 | P34903 |
| 116 | Gamma-aminobutyric-acid receptor alpha-5 subunit | GABRA5 | P31644 |
| 117 | Muscarinic acetylcholine receptor M2 | CHRM2 | P08172 |
| 118 | Muscarinic acetylcholine receptor M3 | CHRM3 | P20309 |
| 119 | Muscarinic acetylcholine receptor M4 | CHRM4 | P08173 |
| 120 | Mu-type opioid receptor | OPRM1 | P35372 |
| 121 | Neuronal acetylcholine receptor protein, alpha-7 chain | CHRNA7 | P36544 |
| 122 | Neuronal acetylcholine receptor subunit alpha-2 | CHRNA2 | Q15822 |
| 123 | Sodium-dependent serotonin transporter | SLC6A4 | P31645 |
| 124 | Transforming growth factor beta-1 | TGFB1 | P01137 |
| 125 | Aldo-keto reductase family 1 member C3 | AKR1C3 | P42330 |
| 126 | Antileukoproteinase | SLPI | P03973 |
| 127 | Apoptosis regulator Bcl-2 | Bcl2 | P10417 |
| 128 | Aryl hydrocarbon receptor | Ahr | P30561 |
| 129 | Cytochrome P450 1A2 | CYP1A2 | P05177 |
| 130 | Gamma-aminobutyric-acid receptor alpha-2 subunit | GABRA2 | P47869 |
| 131 | Glutathione S-transferase Mu 2 | GSTM2 | P28161 |
| 132 | Hyaluronan synthase 2 | HAS2 | Q92819 |
| 133 | Inhibitor of nuclear factor kappa-B kinase subunit beta | IKBKB | O14920 |
| 134 | Mitogen-activated protein kinase 8 | MAPK8 | P45983 |
| 135 | Muscarinic acetylcholine receptor M1 | CHRM1 | P11229 |
| 136 | Nitric oxide synthase, endothelial | NOS3 | P29474 |
| 137 | Nuclear receptor subfamily 1 group I member 2 | NR1I2 | O75469 |
| 138 | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform | PIK3CG | P48736 |
| 139 | Prostaglandin G/H synthase 2 | PTGS2 | P35354 |
| 140 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | PPP3CA | Q08209 |
| 141 | Signal transducer and activator of transcription 1-alpha/beta | STAT1 | P42224 |
| 142 | Sodium-dependent noradrenaline transporter | SLC6A2 | P23975 |
| 143 | Vascular cell adhesion protein 1 | VCAM1 | P19320 |
| 144 | 4-Aminobutyrate aminotransferase, mitochondrial | ABAT | P80404 |
| 145 | Alcohol dehydrogenase 1A | ADH1A | P07327 |
| 146 | Alcohol dehydrogenase 1B | ADH1B | P00325 |
| 147 | Alcohol dehydrogenase 1C | ADH1C | P00326 |
| 148 | Caspase-3 | CASP3 | P42574 |
| 149 | CD44 antigen | CD44 | P16070 |
| 150 | Intercellular adhesion molecule 1 | ICAM1 | P05362 |
| 151 | Tumor necrosis factor | TNF | P01375 |
| 152 | Mineralocorticoid receptor | NR3C2 | P08235 |
| 153 | Progesterone receptor | PGR | P06401 |