Figure 6.

Retroareolar invasive ductal carcinoma in a 54-year-old Ashkenazi Jewish man who presented with a palpable mass in the right breast and who had a family history of breast cancer diagnosed in a sister (at 51 years old), a maternal aunt (at 60 years old), and his maternal grandmother (at 65 years old), as well as melanoma diagnosed in his father (at 65 years old). (a, b) MLO (a) and CC (b) mammographic views show a centrally located retroareolar mass (arrow) in the right breast. (c) Color Doppler US image also shows the mass. Biopsy of the mass was performed, and histopathologic analysis showed an ER-positive, PR-positive, HER2-negative invasive ductal carcinoma. Despite the considerable family history, this patient tested negative for any known genetic mutations.