Table 3:
Representative Differences between Male and Female Breast Cancers
Variable | Male Breast Cancer | Female Breast Cancer |
---|---|---|
Histologic types | >90% IDC, <0.5% ILC | β€90% IDC, 10% ILC |
Molecular markers | >90% ER+, >80% PR+, <0.5%TN | 75% ER+, 65% PR+, 10%β15% TN |
Tumor grade | No correlation with survival | Yes; correlation with survival |
PIK3CA and TP53 mutations | Infrequent | Frequent |
Note.βER = estrogen receptor, IDC = invasive ductal carcinoma, ILC = invasive lobular carcinoma, PIK3CA = phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha gene, PR = progesterone receptor, TN = triple negative, TP53 = tumor protein p53 gene.