Table 3.
Association of most significant GWAS variants per LD block with NRM and RM
| Chr | Gene | SNP | Alleles* | End point | Genome | Model | MAF† | Discovery results | Replication results | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P | HR (95% CI) | P | HR (95% CI) | Power, %‡ | ||||||||
| 6 | MIR548A1HG | rs9350085 | C/T | NRM | Recipient | Allelic | 0.37 | 7.7E−07 | 1.29 (1.2-1.4) | .65 | 0.97 (0.9-1.1) | 100 |
| 6 | LOC105377999 | rs9492413 | C/T | NRM | Donor | Allelic | 0.19 | 9.8E−07 | 1.35 (1.2-1.5) | .86 | 0.99 (0.9-1.1) | 100 |
| 12 | none | rs11451044 | CA/C | NRM | Donor | Allelic | 0.45 | 5.8E−07 | 1.28 (1.2-1.4) | 1.00 | 1.00 (0.9-1.1) | 100 |
| 4 | GBA3 | rs114484584 | C/T | RM | Recipient | Allelic | 0.02 | 2.4E−07 | 2.46 (1.8-3.3) | .23 | 0.63 (0.3-1.4) | 16 |
| 11 | CCDC81 | rs148290359 | C/T | RM | Recipient | Allelic | 0.02 | 2.3E−07 | 0.14 (0.04-0.4) | .46 | 1.23 (0.7-2.1) | 33 |
| 7 | none | rs117446118 | G/A | RM | Donor | Allelic | 0.02 | 8.1E−07 | 2.91 (2.0-4.2) | .10 | 0.60 (0.3-1.2) | 22 |
| 9 | ADAMTSL1 | rs60125430 | C/T | RM | Donor | Allelic | 0.09 | 4.6E−08 | 1.74 (1.4-2.1) | .37 | 1.15 (0.9-1.5) | 77 |
*
Plus strand major/minor alleles.
†
MAF in the samples used for the test.
‡
Post hoc power estimates to detect an HR ≥1.5 or ≤0.67 at a 2-sided significance level of .05 were based on the estimated standard error of the log HR in the replication cohort.