Table 4.
Multivariate analysis of risk factors for NRM in the replication cohort
| Risk factor | HR (95% CI) | P |
|---|---|---|
| Donor rs1051792 (per A allele)* | 0.85 (0.74-0.98) | .02 |
| Donor relation | ||
| Related | 1.0 | |
| Unrelated | 1.17 (0.94-1.46) | .15 |
| HLA match | ||
| Matched | 1.0 | |
| Mismatch | 1.50 (1.22-1.86) | .0002 |
| Donor-recipient sex | ||
| Other | 1.0 | |
| Female to male | 1.41 (1.17-1.70) | .0004 |
| Recipient age (per 10 y) | 1.23 (1.14-1.33) | <.0001 |
| Donor age† (per 10 y) | 1.09 (1.00-1.19) | .05 |
| Graft source | ||
| Bone marrow | 1.0 | |
| Mobilized blood cells | 0.79 (0.64-0.99) | .04 |
| Conditioning | ||
| Myeloablative, <900 cGy TBI | 1.0 | |
| Myeloablative, ≥900 cGy TBI | 1.46 (1.18-1.81) | .0006 |
| Nonmyeloablative | 1.08 (0.81-1.45) | .61 |
*
Supplemental Table 9 summarizes the distribution of genotypes in the replication cohort.
†
Missing donor age was accommodated with indicator variable.