Table 2. Associations of Clinical and Stress CMR Parameters With CV Death and Nonfatal MIa.
| CV death and nonfatal MI | Univariate analysis | Multivariable analysis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P value | Model 1b | Model 2c | Model 1 + CMRb | Model 2 + CMRc | ||||||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | ||||||
| CAD Consortium scored | 1.02 (1.01-1.04) | <.01 | 1.02 (1.01-1.04) | <.01 | 1.02 (1.01-1.04) | <.01 | 1.02 (1.01-1.03) | .02 | 1.02 (1.01-1.03) | .02 | |||
| Hypertension | 2.54 (1.16-5.56) | .02 | NA | NA | 2.30 (1.05-5.06) | .04 | NA | NA | 2.04 (0.93-4.55) | .07 | |||
| Diabetes | 1.69 (1.03-2.76) | .04 | NA | NA | 1.58 (0.96-2.59) | .07 | NA | NA | 1.55 (0.92-2.60) | .10 | |||
| Smoking | 1.92 (1.18-3.12) | <.01 | NA | NA | 1.83 (1.12-2.97) | .02 | NA | NA | 1.91 (1.16-3.16) | .01 | |||
| LVEF, per 5% | 0.81 (0.76-0.87) | <.01 | NA | NA | NA | NA | 0.84 (0.78-0.91) | <.01 | 0.84 (0.77-0.91) | <.01 | |||
| Presence of LGE | 3.49 (2.13-5.73) | <.01 | NA | NA | NA | NA | 1.45 (0.73-2.48) | .22 | 1.34 (0.74-2.42) | .33 | |||
| Presence of ischemia | 3.80 (2.31-6.27) | <.01 | NA | NA | NA | NA | 2.45 (1.40-4.29) | <.01 | 2.21 (1.25-3.92) | <.01 | |||
Abbreviations: CAD, coronary artery disease; CMR, cardiac magnetic resonance; CV, cardiovascular; HR, hazard ratio: LGE, late gadolinium enhancement; LVEF, left ventricular ejection fraction; MI, myocardial infarction; NA, not applicable.
a
Statistical analysis by Cox proportional hazards.
b
Adjusted for CAD Consortium score.
c
Adjusted for CAD Consortium score, hypertension, diabetes, and smoking.
d
The CAD Consortium score assesses the pretest probability for presence of hemodynamically obstructive CAD based on age, sex, and type of chest pain (typical, atypical, or nonspecific). Possible score range is 0% to 100%.