Table 3. Reclassification for CV Death/Nonfatal MI and MACE, After Addition of CMR-Assessed LVEF, Late Gadolinium Enhancement, and Ischemia.
Reclassification metric | CV death and nonfatal MI (95% CI) | MACE (95% CI) | ||
---|---|---|---|---|
Model 1 vs model 1 with CMRa | Model 2 vs model 2 with CMRb | Model 1 vs model 1 with CMRa | Model 2 vs model 2 with CMRb | |
NRI | 0.234 (0.061-0.407) | 0.266 (0.091-0.441) | 0.355 (0.247-0.463) | 0.361 (0.255-0.468) |
Clinical NRI | 0.448 (0.381-0.515) | 0.521 (0.452-0.590) | 0.554 (0.491-0.617) | 0.517 (0.466-0.568) |
NRI at event rate | 0.185 (0.044-0.326) | 0.146 (0.035-0.257) | 0.198 (0.112-0.284) | 0.144 (0.063-0.225) |
IDI | 0.044 (0.025-0.063) | 0.042 (0.023-0.061) | 0.082 (0.061-0.104) | 0.076 (0.055-0.097) |
Abbreviations: CMR, cardiac magnetic resonance; CV, cardiovascular; IDI, integrated discrimination improvement; LVEF, left-ventricular ejection fraction; MACE, major adverse cardiovascular events; MI, myocardial infarction; NRI, net reclassification improvement.
Adjusted for CAD Consortium score, which assesses the pretest probability for presence of hemodynamically obstructive CAD based on age, sex, and type of chest pain (typical, atypical, or nonspecific). Possible score range is 0% to 100%.
Adjusted for CAD Consortium score, hypertension, diabetes, smoking.