Table 3.
Univariate cox regression analyses of pathologic features and molecular markers for the overall survival of 74 hepatocellular carcinoma patients who underwent surgical treatment
| Variables | Univariate | ||
|---|---|---|---|
| Hazard Ratio | 95%CI | p-value | |
| Gender (female vs. male) | 0.336 | 0.046-2.466 | 0.284 |
| Age (<52y vs. ≥52y) | 0.606 | 0.301-1.219 | 0.160 |
| Edmondson grading (I-II vs. III-IV) | 3.029 | 1.398-6.563 | 0.005* |
| Vessel invasion (positive vs. negative) | 1.296 | 0.613-2.739 | 0.497 |
| Tumor size (≤5cm vs. >5cm) | 1.812 | 0.900-3.648 | 0.096 |
| Tumor number (1 vs. 2) | 3.705 | 1.501-9.144 | 0.004* |
| Tumor capsule (complete vs. incomplete) | 1.908 | 0.919-3.961 | 0.083 |
| pT categories (pT1 vs. pT2/pT3) | 2.139 | 1.066-4.289 | 0.032* |
| Cirrhosis (positive vs. negative) | 2.046 | 0.489-8.568 | 0.327 |
| HBsAg (positive vs. negative) | 1.142 | 0.513-2.542 | 0.745 |
| TBiL (3.5-20umol/L vs. >20umol/L) | 1.213 | 0.467-3.151 | 0.691 |
| ALT (0-40U/L vs. >40U/L) | 1.220 | 0.609-2.445 | 0.574 |
| AFP (<100ug/L vs. ≥100ug/L) | 1.365 | 0.681-2.735 | 0.380 |
| CD4/CD8 expression (high vs. low) | 0.559 | 0.276-1.135 | 0.107 |
| PD-L1 expression (high vs. low) | 2.754 | 1.373-5.525 | 0.004* |
| CD276 expression (high vs. low) | 1.633 | 0.806-3.309 | 0.174 |
| SOCS3 expression (high vs. low) | 0.435 | 0.217-0.872 | 0.019* |
*p-value<0.05.