Table 2.
The univariable logistic regression for analyzing the risk factors for early death
| Subject characteristics | Total early death | Cancer specific early death | Non-Cancer specific early death | |||
|---|---|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |
| Age | ||||||
| ≤18 | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| 19-50 | 2.19 (1.57-3.05) | <0.001 | 2.23 (1.48-3.34) | <0.001 | 2.06 (1.16-3.67) | 0.014 |
| >50 | 8.85 (6.50-12.06) | <0.001 | 7.00 (4.79-10.21) | <0.001 | 11.06 (6.51-18.79) | <0.001 |
| Gender | ||||||
| Male | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Female | 0.91 (0.83-1.00) | 0.042 | 0.96 (0.85-1.08) | 0.490 | 0.85 (0.74-0.98) | 0.026 |
| Marital status | ||||||
| Married | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Unmarried | 1.04 (0.94-1.14) | 0.448 | 1.09 (0.96-1.23) | 0.186 | 0.97 (0.84-1.12) | 0.688 |
| Unknown | 0.94 (0.77-1.13) | 0.499 | 0.77 (0.59-1.01) | 0.061 | 1.16 (0.89-1.50) | 0.273 |
| Race | ||||||
| White | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Black | 1.06 (0.91-1.22) | 0.463 | 1.33 (1.12-1.59) | 0.001 | 0.72 (0.56-0.92) | 0.009 |
| Others | 0.91 (0.76-1.08) | 0.268 | 1.04 (0.84-1.29) | 0.726 | 0.76 (0.57-0.99) | 0.045 |
| Unknown | 0.25 (0.12-0.54) | <0.001 | 0.27 (0.10-0.73) | 0.010 | 0.25 (0.08-0.78) | 0.017 |
| Insurance | ||||||
| Insured | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Uninsured | 1.09 (0.85-1.40) | 0.492 | 1.45 (1.09-1.93) | 0.010 | 0.64 (0.40-1.02) | 0.058 |
| Unknown | 1.67 (1.39-2.01) | <0.001 | 1.90 (1.51-2.38) | <0.001 | 1.29 (0.96-1.73) | 0.093 |
| Primary Site | ||||||
| Bone | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Soft tissue | 1.42 (1.25-1.60) | <0.001 | 1.50 (1.28-1.77) | <0.001 | 1.28 (1.07-1.53) | 0.008 |
| Location | ||||||
| Extremities | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Head and neck | 2.13 (1.86-2.44) | <0.001 | 2.13 (1.77-2.56) | <0.001 | 2.02 (1.65-2.46) | <0.001 |
| Trunk | 2.90 (2.59-3.26) | <0.001 | 3.03 (2.60-3.53) | <0.001 | 2.51 (2.12-2.98) | <0.001 |
| Unknown | 9.71 (8.26-11.42) | <0.001 | 10.38 (8.52-12.65) | <0.001 | 5.85 (4.61-7.42) | <0.001 |
| Grade | ||||||
| Grade I | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Grade II | 1.51 (1.08-2.09) | 0.015 | 1.63 (0.99-2.66) | 0.054 | 1.40 (0.91-2.16) | 0.126 |
| Grade III | 4.78 (3.63-6.29) | <0.001 | 6.70 (4.45-10.10) | <0.001 | 3.09 (2.135-4.48) | <0.001 |
| Grade IV | 5.31 (4.07-6.93) | <0.001 | 6.47 (4.33-9.69) | <0.001 | 4.08 (2.87-5.79) | <0.001 |
| Unknown | 5.83 (4.49-7.56) | <0.001 | 8.13 (5.47-12.07) | <0.001 | 3.71 (2.63-5.23) | <0.001 |
| Laterality | ||||||
| Left-sided | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Right-sided | 0.84 (0.73-0.96) | 0.013 | 0.77 (0.63-0.93) | 0.006 | 0.94 (0.76-1.15) | 0.515 |
| One side, NOS | 2.94 (2.63-3.30) | <0.001 | 3.04 (2.62-3.52) | <0.001 | 2.49 (2.10-2.95) | <0.001 |
| Paired sides | 4.11 (2.92-5.77) | <0.001 | 3.79 (2.45-5.84) | <0.001 | 3.75 (2.32-6.05) | <0.001 |
| Stage | ||||||
| Localized | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Regional | 2.39 (2.06-2.76) | <0.001 | 3.08 (2.49-3.80) | <0.001 | 1.84 (1.51-2.24) | <0.001 |
| Distant | 10.76 (9.51-12.17) | <0.001 | 16.39 (13.74-19.54) | <0.001 | 4.90 (4.13-5.81) | <0.001 |
| Unknown | 7.14 (6.07-8.41) | <0.001 | 8.85 (7.05-11.11) | <0.001 | 4.95 (3.97-6.18) | <0.001 |
| T stage | ||||||
| T1 | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| T2 | 2.52 (2.16-2.95) | <0.001 | 3.61 (2.86-4.56) | <0.001 | 1.70 (1.38-2.09) | <0.001 |
| T3 | 2.54 (1.27-5.08) | 0.008 | 4.17 (1.78-9.73) | 0.001 | 1.37 (0.43-4.36) | 0.596 |
| Unknown | 7.81 (6.69-9.12) | <0.001 | 10.72 (8.50-13.51) | <0.001 | 4.69 (3.82-5.76) | <0.001 |
| N stage | ||||||
| N0 | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| N1 | 3.21 (2.73-3.77) | <0.001 | 3.85 (3.18-4.68) | <0.001 | 2.06 (1.59-2.68) | <0.001 |
| Unknown | 4.01 (3.60-4.47) | <0.001 | 4.20 (3.66-4.82) | <0.001 | 3.07 (2.61-3.60) | <0.001 |
| Bone Met | ||||||
| No | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Yes | 5.33 (4.61-6.15) | <0.001 | 6.36 (5.38-7.52) | <0.001 | 2.85 (2.26-3.59) | <0.001 |
| Unknown | 3.62 (3.12-4.20) | <0.001 | 3.62 (3.00-4.36) | <0.001 | 2.98 (2.40-3.69) | <0.001 |
| Brain Met | ||||||
| No | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Yes | 9.71 (6.85-13.75) | <0.001 | 10.98 (7.58-15.91) | <0.001 | 3.78 (2.20-6.51) | <0.001 |
| Unknown | 3.33 (2.88-3.85) | <0.001 | 3.27 (2.73-3.92) | <0.001 | 2.79 (2.26-3.45) | <0.001 |
| Liver Met | ||||||
| No | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Yes | 7.65 (6.45-9.08) | <0.001 | 8.58 (7.07-10.40) | <0.001 | 3.81 (2.94-4.95) | <0.001 |
| Unknown | 3.64 (3.14-4.21) | <0.001 | 3.73 (3.11-4.47) | <0.001 | 2.87 (2.32-3.56) | <0.001 |
| Lung Met | ||||||
| No | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Yes | 6.12 (5.46-6.85) | <0.001 | 8.18 (7.14-9.38) | <0.001 | 2.81 (2.34-3.37) | <0.001 |
| Unknown | 4.43 (3.82-5.14) | <0.001 | 4.87 (4.04-5.87) | <0.001 | 3.21 (2.59-3.97) | <0.001 |
| Surgery | ||||||
| No Surgery | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Local Surgery | 0.09 (0.08-0.10) | <0.001 | 0.08 (0.07-0.10) | <0.001 | 0.14 (0.11-0.17) | <0.001 |
| Partial Surgery | 0.12 (0.09-0.15) | <0.001 | 0.10 (0.07-0.15) | <0.001 | 0.19 (0.13-0.26) | <0.001 |
| Radical Surgery* | 0.05 (0.05-0.06) | <0.001 | 0.05 (0.04-0.06) | <0.001 | 0.08 (0.06-0.10) | <0.001 |
| Amputation | 0.09 (0.07-0.13) | <0.001 | 0.10 (0.07-0.16) | <0.001 | 0.12 (0.07-0.19) | <0.001 |
| Unknown | 0.30 (0.23-0.40) | <0.001 | 0.39 (0.28-0.55) | <0.001 | 0.25 (0.15-0.41) | <0.001 |
*Radical excision or resection of lesion with limb salvage;
Abbreviations: OR = Odds ratio; CI = Confidence interval; Ref = Reference.