Table 1.

The side effects caused by CAR-T cell therapy

Side Effect	Pathogenesis	Symptom	Reference
Cytokine Release Syndrome	Dramatic increases of inflammatory cytokines	High-grade fevers, Respiratory insufficiency, Hypotension, Neurologic dysfunction	62-65
Cerebral Edema	Blood-brain barrier, High cytokine levels, Astrocyte dysfunction	Seizures, Cognitive dysfunction, Focal neurologic deficits	66-68
Tumor Relapse	Antigen loss, Deleterious mutations, Dysfunction and exhaustion of CAR-T cell	Tumor growth, invasion and recidivism	69-75