Figure 1.

Establishment of HCC-DD model with DEN and reserpine. (A) Mice received 25 mg/kg DEN on the 14th and 30th days and were then induced by reserpine every two days starting on day 21. (B) The table was used to identify depressive disorder by determining scores. (C) The growth curve of the mice. (D) Depressive disorder score of the HCC and HCC-DD groups; (E, F) Food intake curve for every single day (G) The time of immobility in water during the forced swim test. (H) Liver tumor image of mouse model. (I) HE staining of the liver tissue. **p < 0.01, ***p < 0.005.