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. 2020 Jul 9;11(18):5309–5317. doi: 10.7150/jca.45712

Figure 4.

Figure 4

Depressive disorder promotes metastasis in an AKT-dependent manner. (A) The migration ability of cells in the HCC-DD group was dramatically increased, as determined by a wound-healing assay. (B) Quantification of the wound-healing assay. (C) Western blotting of EMT markers in HCC and HCC-DD primary cell cultures. (D) PTEN, AKT, and p-AKT levels in HCC and HCC-DD primary culture cells. Schematic illustration of how reserpine affects the AKT pathway, regulates ABCG2, and then promotes metastasis and CSC function (E).