Table 1.
Association between clinical characteristics and the expression level of key necroptotic genes
| Variables | No of patients | RIPK1 | RIPK3 | MLKL | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Low | High | P | Low | High | P | Low | High | P | ||
| Age | 64.9 (±9.1) | 64.1(±9.3) | 0.50 | 64.6(±9.5) | 64.3(±8.9) | 0.82 | 64.6(±9.7) | 64.3(±8.7) | 0.80 | |
| Gender | ||||||||||
| Male | 173 | 85(49.1) | 88(50.9) | 0.90 | 101(58.4) | 72(41.6) | 6×10-5 | 85(49.1) | 88(50.9) | 0.75 |
| Female | 80 | 40(50.0) | 40(50.0) | 25(31.2) | 55(68.8) | 41(51.2) | 39(48.8) | |||
| Smoking status | ||||||||||
| Smoker | 168 | 80(47.6) | 88(52.4) | 0.42 | 95(56.5) | 73(43.5) | 3×10-3 | 81(48.2) | 87(51.8) | 0.48 |
| Non-smoker | 85 | 45(52.9) | 40(47.1) | 31(36.5) | 54(63.5) | 45(52.9) | 40(47.1) | |||
| Histologic type | ||||||||||
| SCC | 96 | 46(47.9) | 50(52.1) | 0.71 | 62(64.6) | 34(35.4) | 2×10-4 | 40(41.7) | 56(58.3) | 0.04 |
| AC | 157 | 79(50.3) | 78(49.7) | 64(40.8) | 93(59.2) | 86(54.8) | 71(45.2) | |||
| Smoker | 74 | 35(47.3) | 39(52.7) | 0.48 | 34(45.9) | 40(54.1) | 0.21 | 42(56.8) | 32(43.2) | 0.64 |
| Non-smoker | 83 | 44(53.0) | 39(47.0) | 30(36.1) | 53(63.9) | 44(53.0) | 39(47.0) | |||
| EGFR mutant | 45 | 21(46.7) | 24(53.3) | 0.50 | 21(46.7) | 24(53.3) | 0.35 | 28(62.2) | 17(37.8) | 0.25 |
| EGFR wild | 89 | 47(52.8) | 42(47.2) | 34(38.2) | 55(61.8) | 46(51.7) | 43(48.3) | |||
| Pathologic stage | ||||||||||
| Stage I | 210 | 100(47.6) | 110(52.4) | 0.21 | 100(47.6) | 110(52.4) | 0.13 | 106(50.5) | 104(49.5) | 0.64 |
| Stage II-III | 43 | 25(58.1) | 18(41.9) | 26(60.5) | 17(39.5) | 20(46.5) | 23(53.5) | |||
| Adjuvant CTx | ||||||||||
| Yes | 52 | 26(50.0) | 26(50.0) | 0.92 | 28(53.8) | 24(46.2) | 0.51 | 24(46.2) | 28(53.8) | 0.56 |
| No | 201 | 99(49.3) | 102(50.7) | 98(48.8) | 103(51.2) | 102(50.7) | 99(49.3) | |||
Abbreviations: RIPK1, Receptor-interacting protein kinase 1; RIPK3, Receptor-interacting protein kinase 3; MLKL, Mixed-lineage kinase domain like pseudokinase; SCC, Squamous cell carcinoma; AC, Adenocarcinoma; CTx, Chemotherapy.Data are expressed as the mean (±SD) or number (%).