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miR-154-5p can bind to CUL2 3'UTR directly. (A) Bioinformatics analysis predicted that CUL2 3'UTR was potentially targeted by 17 differentially expressed miRNAs. (B) The putative binding sites of CUL2 3'UTR and miR-154-5p. (C) miR-154-5p sequence is highly conserved. (D) Dual-luciferase report assays of cells cotransfected with miR-154-5p mimic and wild-type or mutant luciferase reporter. (*, P<0.05 versus corresponding NC).
