Table 3.
Evaluation of the detection value of L1CAM in the diagnosis of GC and EJA
| Group | AUC (95%CI) | Sensitivity | Specificity | FPR | FNR | PPV | NPV | PLR | NLR |
|---|---|---|---|---|---|---|---|---|---|
| All-stage | |||||||||
| GC vs. NC | 0.769 (0.715-0.823) | 83.1% | 62.2% | 37.8% | 16.9% | 68.7% | 78.6% | 2.20 | 0.27 |
| EJA vs. NC | 0.672 (0.590-0.755) | 66.1% | 62.2% | 37.8% | 33.9% | 41.1% | 82.1% | 1.75 | 0.55 |
| GC+EJA vs. NC | 0.742 (0.689-0.794) | 78.3% | 64.2% | 35.8% | 21.7% | 74.3% | 67.2% | 2.07 | 0.35 |
| Early-stage | |||||||||
| GC vs. NC | 0.681 (0.596-0.766) | 76.6% | 62.2% | 37.8% | 23.4% | 39.1% | 89.3% | 2.02 | 0.38 |
| EJA vs. NC | 0.674 (0.528-0.820) | 69.2% | 62.2% | 37.8% | 30.8% | 13.8% | 95.8% | 1.83 | 0.49 |
| GC+EJA vs. NC | 0.679 (0.601-0.758) | 75.0% | 62.2% | 37.8% | 25.0% | 44.6% | 86.0% | 1.98 | 0.40 |
AUC, area under the curve; 95% CI, 95% confidence interval; GC: gastric cancer; EJA: esophagogastric junctional adenocarcinomas; NC, normal controls; FNR, false negative rate; FPR, false positive rate; PPV, positive predictive value; NPV, negative predictive value; PLR, positive likelihood ratio; NLR, negative likelihood ratio.