Table 3.
Univariable and multivariable analyses estimating the association of presenting features on mortality in older patients with COVID-19
| Univariable models | Multivariable model | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | p | |
| Age | 1.03 | (1.01–1.06) | 0.02 | 1.06 | (1.03–1.09) | < 0.01 |
| Sex | 1.25 | (0.84–1.86) | 0.26 | 1.22 | (0.80–1.87) | 0.36 |
| CFS | 1.02 | (0.93–1.12) | 0.71 | |||
| Cough | 1.45 | (0.98–2.15) | 0.07 | 1.17 | (0.75–1.84) | 0.49 |
| Fever | 1.75 | (1.09–2.82) | 0.02 | 1.97 | (1.14–3.41) | 0.02 |
| Dyspnoea | 2.14 | (1.37–3.35) | < 0.01 | 1.96 | (1.16–3.29) | 0.01 |
| Gastrointestinal | 0.43 | (0.11–1.74) | 0.24 | 0.45 | (0.11–1.91) | 0.28 |
| Imaging abnormalities | 1.55 | (1.08–2.22) | 0.02 | 1.23 | (0.81–1.86) | 0.33 |
| Falls | 0.91 | (0.59–1.4) | 0.68 | 0.89 | (0.55–1.44) | 0.64 |
| Reduced mobility | 1.1 | (0.76–1.6) | 0.61 | 0.75 | (0.47–1.2) | 0.23 |
| Delirium | 1.28 | (0.87–1.88) | 0.21 | 1.91 | (1.2–3.04) | < 0.01 |
| CRP (quartiles) | < 0.01 | < 0.01 | ||||
| 2 | 1.3 | (0.73–2.31) | 0.38 | 1.56 | (0.81–3) | 0.18 |
| 3 | 1.88 | (1.07–3.3) | 0.03 | 2.52 | (1.29–4.94) | < 0.01 |
| 4 | 2.37 | (1.38–4.06) | < 0.01 | 3.03 | (1.6–5.74) | 0.01 |
| Neurotophil: lymphocytes (quartiles) | 0.13 | 0.04 | ||||
| 2 | 0.98 | (0.58–1.68) | 0.96 | 0.86 | (0.47–1.59) | 0.64 |
| 3 | 0.82 | (0.48–1.42) | 0.49 | 0.54 | (0.29–1) | 0.05 |
| 4 | 1.52 | (0.92–2.51) | 0.1 | 1.23 | (0.67–2.25) | 0.5 |
HR hazard ratio; CI confidence interval; CFS Clinical Frailty Scale; CRP C-reactive protein