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. 2020 May 8;30(9):4811–4833. doi: 10.1093/cercor/bhaa072

Figure 3.

Figure 3

The PB contains two different populations of neurons that express Cck, with separate output targets. (A) Summary diagram of the projections from caudal–medial and rostral–lateral Cck-expressing neurons in the PB. (B) FG injection site in the medial hypothalamus (case #01939). (C–D) Many of the retrogradely labeled (blue) neurons in the rostral-lateral PB expressed Cck (C, red) or contained nuclear immunoreactivity for FoxP2 (D, green). (E–G) FG injections in the hypothalamus (n = 2) labeled many Cck-expressing neurons in the rostral, lateral PB, but not in the caudal–medial PB. Many of these were FoxP2-immunoreactive. (H) FG injections in the cortex did not label any Cck-expressing neurons in the rostral-lateral PB and instead labeled many in the caudal-medial PB. Most contained nuclear immunoreactivity for Lmx1b and lacked FoxP2 (n = 9). The distribution of retrogradely labeled and Cck-expressing neurons in a representative case is shown at right (F-G, hypothalamic case #01939; I-J, cortex case #00563) (additional abbreviations: cL, central lateral PB subnucleus; sL, superior lateral PB subnucleus).