Table 1. Percent Chemosuppression in Mice after Treatment with Various Concentrations (10–100 mg/kg) of 9a in Monotherapya.
| monotherapy groups | ||||
|---|---|---|---|---|
| groups, n = 5 | dose (D0–D3) (0.2 mL/(mouse OD oral)) D0—i.p. inoculation (1 × 106P. berghei-infected RBCs) | parasitemia (%), day 5 | chemosuppression (%), day 5 | parasitemia (%), day 28 |
| G1 | normal control | |||
| G2 | infected control | 29.09 ± 7.95 (n = 5) | – (n = 0) | |
| G3 | vehicle control | 30.7 ± 5.22 (n = 5) | ||
| G4 | 9a (10 mg/kg) | 17.31 ± 2.40** (n = 5) | 40.49 | – (n = 0) |
| G5 | 9a (20 mg/kg) | 15.47 ± 2.69** (n = 5) | 46.82 | – (n = 0) |
| G6 | 9a (50 mg/kg) | 10.25 ± 4.93*** (n = 5) | 64.76 | 3.43 ± 0.51 (n = 2) |
| G7 | 9a (100 mg/kg) | 2.56 ± 1.71*** (n = 5) | 91.19 | 2.41 ± 0.97 (n = 3) |
| G8 | artesunate (4 mg/kg) | 1.74 ± 0.83*** (n = 5) | 94.01 | – (n = 0) |
| G9 | artesunate (50 mg/kg) | 0.03 ± 0.01*** (n = 5) | 99.89 | 0 ± 0 (n = 2) |
| G10 | chloroquine (10 mg/kg) | 1.68 ± 1.06*** (n = 5) | 94.22 | 0 ± 0 (n = 5) |
a
Data are presented as mean ± standard deviation (SD) for five mice per group. n = total no. of mice in each group. p-Value in comparison to control is shown as ***p < 0.0005, extremely statistically significant; **p < 0.005, very statistically significant.