Table 2. Percent Chemosuppression in Mice after Treatment with 9a in Combination Therapy with Artesunatea.
| combination
therapy groups | ||||
|---|---|---|---|---|
| groups, n = 5 | dose (D0–D3) (0.2 mL/(mouse OD oral)) D0—ip inoculation (1 × 106P. berghei-infected RBCs) | parasitemia (%), day 5 | chemosuppression (%), day 5 | parasitemia (%), day 28 |
| G1 | normal control | |||
| G2 | infected control | 29.09 ± 7.95 (n = 5) | – (n = 0) | |
| G3 | vehicle control | 30.7 ± 5.22 (n = 5) | – (n = 0) | |
| G4 | 9a (100 mg/kg) + artesunate (4 mg/kg) | 2.65 ± 2.44*** (n = 5) | 90.89 | – (n = 0) |
| G5 | 9a (100 mg/kg) + artesunate (50 mg/kg) | 0.09 ± 0.13*** (n = 5) | 99.69 | 0 ± 0 (n = 4) |
| G6 | artesunate (50 mg/kg) + sulfadoxine (25 mg/kg) – pyrimethamine (1.2 mg/kg) | 2.46 ± 0.1*** (n = 5) | 91.54 | 0 ± 0 (n = 5) |
a
Data are presented as mean ± SD for five mice per group. n = total no. of mice in each group. p-Value in comparison to control is shown as ***p < 0.0005, extremely statistically significant.