Table 4. Liver and Kidney Function Tests in Mice Treated with Combination of 9a and Artesunate on D10 and D28a.
| groups, n = 5 | dose (D0–D3) (0.2 mL/(mouse OD oral)) | ALP (IU/L) | bilirubin (mg/dL) | SGOT (IU/L) | SGPT (IU/L) | urea (mg/dL) | creatinine (mg/dL) |
|---|---|---|---|---|---|---|---|
| G1 | normal control | 90.41 ± 6.51 | 0.43 ± 0.14 | 38.40 ± 4.94 | 68.72 ± 8.05 | 28.68 ± 3.75 | 0.68 ± 0.3 |
| G2 | infected control | 152.55 ± 9.44*** | 1.56 ± 0.28*** | 143.8 ± 5.31*** | 106.79 ± 4.87*** | 45.21 ± 5.83*** | 1.92 ± 0.21*** |
| G3 | vehicle control (SSV) | 165.6 ± 7.87*** | 1.67 ± 0.20*** | 148.56 ± 4.28*** | 100.58 ± 4.75*** | 40.97 ± 5.17*** | 1.78 ± 0.31*** |
| G4 | 9a (100 mg/kg) + AS (4 mg/kg) | 104.62 ± 0.57*** | 0.97 ± 0.08** | 97.37 ± 2.03*** | 95.03 ± 1.61*** | 37.44 ± 1.65* | 1.02 ± 0.01*** |
| G5 | 9a (100 mg/kg) + AS (50 mg/kg) | ||||||
| day 10 | 96.65 ± 1.05*** | 0.65 ± 0.21*** | 65.73 ± 1.83*** | 82.66 ± 3.47*** | 25.51 ± 2.92*** | 0.81 ± 0.13*** | |
| day 28 | 94.51 ± 2.22 | 0.41 ± 0.02 | 83.19 ± 0.30 | 76.07 ± 2.92 | 31.05 ± 1.34 | 0.67 ± 0.04 | |
| G6 | AS + SP | ||||||
| day 10 | 93.21 ± 4.1*** | 0.33 ± 0.04** | 93.56 ± 4.90*** | 43.49 ± 1.6*** | 26.3 ± 0.75*** | 0.5 ± 0.13*** | |
| day 28 | 95.2 ± 9 | 0.33 ± 0.1 | 80.11 ± 2.84 | 25.93 ± 1.6 | 23.15 ± 1.1 | 0.4 ± 0.2 |
a
Data are presented as mean ± SD for five mice per group. n = total no. of mice in each group. p-Value in comparison to the infected control is shown as ***p < 0.0005, extremely statistically significant; **p < 0.005, very statistically significant; *p < 0.05, statistically significant.