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. 2020 Jul 29;13:107. doi: 10.1186/s12920-020-00756-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Hsa_circ_0002130-hsa_miR_4482-3p-NBN interaction axis. a The circRNA-miRNA-mRNA interaction network was predicted using online bioinformatics programs (Circinteractome, Circbank, TargetScan, and miRBase). The red circle indicated the up-regulated circRNAs, the green indicated the down-regulated ones, the arrow and the hexagon indicated miRNAs and target genes respectively. b The predicted binding sites between hsa_circ_0002130 and hsa_miR_4482-3p were exhibited. c The expression of hsa_circ_0002130 in PANC-1 cells (Left) and PDX tumors (Right) were examined respectively by qRT-PCR. d The expression of NBN was determined by qRT-PCR in samples of sequencing, PANC-1 and SW1990. *p-value < 0.05 and data indicated the mean ± SD. e The survival data from TCGA (Log rank p-value = 0.0234)