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. 2020 Jul 30;21:187. doi: 10.1186/s13059-020-02098-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Impact of miRNA levels on gene expression. a Distribution of the number of associated miRNAs per gene according to the experimental condition. b Enrichment or depletion of miRNA targets among genes whose transcription level correlates with miRNA expression (co-transcribed genes). For each miRNA, odds ratios are reported separately for genes whose transcription is positively (red) or negatively (blue) correlated to miRNA expression. Enrichments are displayed only for miRNAs that have a significant enrichment of their targets in either positively or negatively correlated genes (5% FDR). c, d Percentage of gene expression variance that is attributable, at the basal state, to either transcription or miRNA variation. For miRNAs, attributable variance is also reported considering only negative associations, or negative associations with predicted binding between the gene and the miRNA. c Global percentages (average values across all genes). d Distribution at the gene level. Pie charts indicate the percentage of genes associated with transcription or miRNAs. Violin plots display the distribution of the variance attributable to each factor, among significantly-associated genes. e Global percentage of variance attributable to transcription according to the experimental condition. f Within each experimental condition, pie charts indicate the percentage of genes associated to at least one miRNA. Violin plots display the variance attributable to miRNAs among significantly associated genes