Table 3.
Multivariate Cox regression model for PFS and OS
| Variable | PFS | OS | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | |
| Age | 1.003 | 0.98–1.03 | 0.833 | 1.002 | 0.98–1.03 | 0.853 |
| FHOD1 | ||||||
| Low expression | 1 | 1 | ||||
| High expression | 1.19 | 0.57–2.46 | 0.643 | 1.0 | 0.50–2.02 | 1.000 |
| INF2 | ||||||
| Low expression | 1 | 1 | ||||
| High expression | 2.33 | 1.05–5.18 | 0.038* | 2.22 | 1.04–4.77 | 0.041* |
| Pre-operative KPS | 0.145 | 0.019* | ||||
| 100 | 1 | 1 | ||||
| 90 | 0.81 | 0.30–2.12 | 0.674 | 0.39 | 0.15–1.07 | 0.068 |
| 80 | 1.25 | 0.48–3.31 | 0.648 | 0.75 | 0.28–2.02 | 0.568 |
| 70 | 1.29 | 0.48–3.46 | 0.619 | 1.12 | 0.42–2.98 | 0.82 |
| 60 | 2.05 | 0.70–6.02 | 0.191 | 1.80 | 0.62–5.23 | 0.281 |
| 50 | 1.76 | 0.56–5.52 | 0.335 | 1.38 | 0.44–4.33 | 0.583 |
| 40 | 1.55 | 0.41–5.79 | 0.516 | 1.03 | 0.28–3.88 | 0.962 |
| 30 | 6.72 | 1.23–36.85 | 0.028 | 5.40 | 0.99–29.6 | 0.052 |
| 20 | 1.55 | 0.30–7.99 | 0.603 | 1.51 | 0.29–7.76 | 0.623 |
| 10 | 62.8 | 3.56–1109.3 | 0.005 | 39.8 | 2.28–693.2 | 0.012 |
| Resection | ||||||
| Gross total | 1 | 1 | ||||
| Subtotal | 2.34 | 1.17–4.69 | 0.016* | 1.69 | 0.83–3.43 | 0.151 |
| Post-operative treatment | < 0.001** | < 0.001** | ||||
| RT + TMZ | 1 | 1 | ||||
| RT only | 2.34 | 1.22–4.48 | 0.010 | 2.47 | 1.31–4.67 | 0.005 |
| None | 7.34 | 2.79–19.29 | < 0.001 | 7.97 | 3.00–21.15 | < 0.001 |
Abbreviations: KPS Karnofsky Performance Scale, RT Radiotherapy, TMZ Temozolomide