Table 3.
Characteristics in subgroups based on WMH severity in CD patients.
| Grade 0 (n = 35) | Grade 1 (n = 40) | Grade 2 (n = 26) | |
|---|---|---|---|
| Clinical characteristics | |||
| Gender(female/male) | 27/6 | 35/7 | 23/3 |
| Age (years) | 29.4 ± 9.1 | 38.6 ± 10.9** | 46.61 ± 12.58##** |
| Disease course (years) | 2.97 ± 2.58 | 4.06 ± 3.06 | 5.27 ± 4.54* |
| Smoking history (n) | 1 (3.03%) | 0 (0) | 2 (8.69%) |
| Drinking history (n) | 1 (3.03%) | 3 (7.14%) | 2 (7.69) |
| BMI (kg/m2) | 24.98 ± 4.26 | 24.63 ± 3.04 | 25.62 ± 3.19 |
| Waist circumstance (cm) | 90.05 ± 11.54 | 91.92 ± 8.89 | 93.73 ± 10.06 |
| SBP (mmHg) | 142.3 ± 21.2 | 150.4 ± 24.3 | 148.5 ± 17.5 |
| DBP (mmHg) | 96.7 ± 14.1 | 100.8 ± 18.4 | 94.1 ± 10.7 |
| Hypertension (%) | 66.67% | 83.33% | 80.76% |
| Fasting blood glucose (mmol/L) | 5.10 ± 0.92 | 6.19 ± 2.37* | 6.39 ± 2.68* |
| 2 h-postprandial glucose (mmol/L) | 8.39 ± 4.89 | 9.68 ± 6.14 | 12.24 ± 4.84** |
| Diabetes (%) | 27.27% | 54.76%* | 57.69%* |
| TG (mmol/L) | 1.36 ± 0.78 | 1.52 ± 0.78 | 2.02 ± 1.51* |
| TC (mmol/L) | 5.37 ± 1.30 | 5.20 ± 1.22 | 5.64 ± 1.21 |
| LDL-C (mmol/L) | 3.16 ± 1.11 | 2.98 ± 1.03 | 3.33 ± 1.03 |
| Arrythmia (%) | 9.1% | 16.67% | 19.23%** |
| LVH (%) | 25% | 66.67%** | 77.27%** |
| Anterior pituitary function | |||
| GH (ng/ml) | 0.28 (1.53) | 0.29 (0.76) | 0.15 (0.22) |
| TSH (mIU/L) | 1.23 (2.26) | 1.10 (1.59) | 1.01 (1.52) |
| FT4 (pmol/L) | 13.67 ± 2.76 | 12.74 ± 2.63 | 11.60 ± 3.77* |
| FT3 (pmol/L) | 3.49 ± 0.83 | 3.14 ± 0.65 | 3.03 ± 0.76 |
| PRL (ng/ml) | 13.99 (24.25) | 22.58 (34.88) | 18.80 (28.1) |
| ACTH (ng/L) | 60.9 (110.0) | 74.09 (110.35) | 67.0 (98.6) |
| PTC-8 am (nmol/L) | 834.2 ± 254.1 | 926.4 ± 305.3 | 836.3 ± 281.2 |
| PTC-0 am (nmol/L) | 640 (781.4) | 638 (917.6) | 626.3 (912.2) |
| UFC (ug/24 h) | 737.3 (1634.2) | 911.4 (1,382.8) | 872.0 (1,195.0) |
| Hypothyroidism (%) | 14.3% | 27.5% | 42.3% * |
| Hypogonadism (%) | 31.4% | 42.8% | 35.3% |
| MRI findings | |||
| Hippocampal height (mm) | 7.11 ± 1.07 | 6.97 ± 1.03 | 6.94 ± 1.34 |
| Width of temporal horn (mm) | 3.45 ± 0.95 | 3.81 ± 1.26 | 3.60 ± 1.49 |
| SFR | 0.0313 ± 0.0086 | 0.0317 ± 0.0085 | 0.0369 ± 0.0108#* |
| FFR | 0.0278 ± 0.0071 | 0.0277 ± 0.0132 | 0.0317 ± 0.0180 |
| Uncotemporal index | 0.2106 ± 0.0987 | 0.2006 ± 0.0263 | 0.2023 ± 0.0290 |
| BFR | 0.2954 ± 0.0194 | 0.3072 ± 0.0241* | 0.3086 ± 0.0257* |
| BCR | 0.0862 ± 0.0153 | 0.0965 ± 0.0187* | 0.0994 ± 0.0229** |
| Third ventricle width (mm) | 4.32 ± 1.22 | 4.71 ± 1.48 | 5.48 ± 1.90**# |