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. 2020 Jul 29;10:12779. doi: 10.1038/s41598-020-69619-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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GPNMB, LYVE1 and MMP1 are the most significantly downregulated genes in HSP70 knockdown cells. Heatmap of normalized counts of the top 19 differentially expressed genes and HSP70 in negative control and HSP70 knockdown cells in experimental replicates (n = 3; A). mRNA levels of selected differentially expressed genes analyzed by qRT-PCR (B).