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. 2020 Jul 29;10:12761. doi: 10.1038/s41598-020-69691-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differentially expressed miRNAs and co-expression of miRNAs and their host genes. (A) Volcano plot showing the relative expression change of 514 miRNAs between patients from the short-lived and long-lived subgroup. miRNAs with a significant change in expression (q < 0.1) are colored, others in gray. (B) Correlation of miRNA and corresponding host gene expression values across 42 DNMT3A-mutated patients. Pearson correlation coefficients were set to zero (dashed vertical line, yellow coloring) for miRNAs without a protein-coding host gene. For both figure panels, triangles indicate miRNAs that show (white) or do not show (turquoise) a significant coexpression (positive correlation) with their respective host gene (q < 0.1).