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. 2020 Jul 29;10:12761. doi: 10.1038/s41598-020-69691-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gene and miRNA regulatory network. Nodes represent either genes that are differentially expressed between the two patient subgroups or miRNAs selected as predictors during network inference. Nodes are colored according to whether a gene/miRNA shows an increase or decrease in expression in the short-lived relative to the long-lived patient subgroup. Gene/miRNA names are shown for putative regulator nodes (out-degree > 0) with node sizes being proportional to their out-degree. Potential activating and repressing links are shown in yellow and green color, respectively; only links present in at least two-thirds of the networks were considered. Note that links can represent direct or indirect regulatory dependencies or may only represent correlations.