Table 2.
Non-HOX network modules and potential major regulators.
| Regulator gene | GeneCards annotation summary |
|---|---|
| Network module 1 | |
| SLC4A1 | Anion exchanger; role in O2/CO3 exchange in erythrocytes |
| HBM | Hemoglobin subunit Mu; iron ion and oxygen binding |
| RHD | Rh blood group D antigen; ammonium transmembrane transporter activity |
| GYPA | erythrocyte membrane protein; MN blood group receptor; hematopoietic stem cell differentiation; associated with Anemia, Autoimmune Hemolytic |
| CA1 | Carbonate dehydratase and hydro-lyase activity; highest concentration in erythrocytes; nitrogen metabolism |
| Network module 2 | |
| ZAP70 | T cell receptor associated kinase; T cell development; lymphocyte activation |
| CD3D | Part of T cell receptor/CD3 complex; associated with immunodeficiencies |
| EVL | Enhances actin nucleation and polymerization; actin and profilin binding |
| IFITM1 | Interferone-induced transmembrane protein; antiviral activity; cell adhesion and control of cell growth and migration; regulates osteoblast differentiation |
| Network module 3 | |
| TNFRSF17 | TNF receptor of major B lymphocytes; autoimmune response; transduces signals for cell survival and proliferation |
| IGKV4-1 | V segment of variable domain of immunoglobulin light chain |
| IGKC | Constant region of immunoglobulin heavy chains |
| Network module 4 | |
| GYPC | Erythrocyte membrane protein; Gerbich blood group; response to elevated platelet cytosolic Ca2+; regulation of mechanical cell stability |
| MREG | Melanoregulin; incorporation of pigments into hair; membrane fusing |
| Network module 5 | |
| SORL1 | Transmembrane signaling receptor activity; low-density lipoprotein binding |
| C1QTNF4 | Pro-inflammatory cytokine; activation of NF-kappa-B; IL6 up-regulation |
| Network module 6 | |
| RPS3 | Ribosomal protein; mRNA activation |
| RPS19 | Ribosomal protein; mRNA activation; associated with anemia |